Knee Injections Explained: PRP vs Hyaluronic Acid vs Arthrosamid vs Steroid

A patient recently brought a list to her appointment.

She said:

“I’ve been told I might need an injection… but there seem to be so many different types.”

After we talked through the differences, she felt much clearer about what might suit her situation.

Why Injections Are Used

Knee injections may be used for:

• Osteoarthritis

• Tendon-related pain

• Inflammation within the joint

• Persistent symptoms despite rehabilitation

They are often considered when symptoms haven’t fully improved with physiotherapy alone, or when pain is starting to limit activity.

Types of Knee Injections

Steroid

Steroid injections are commonly used to reduce inflammation within the joint.

• Often provide relatively quick pain relief

• Typically used for flare-ups or more inflamed knees

• The effect may be temporary

They can be helpful in settling symptoms, particularly when pain is more acute.

Hyaluronic Acid

Hyaluronic acid is a substance naturally found in joint fluid.

• Aims to improve lubrication within the knee

• May help with movement and comfort

• Often used in mild to moderate arthritis

Results can vary, and it may be more suitable in earlier stages.

PRP (Platelet-Rich Plasma)

PRP uses a small sample of your own blood, which is processed and injected into the knee.

• Contains growth factors involved in tissue repair

• Aims to support healing and improve function

• Often considered for active patients or earlier-stage problems

Improvement is usually gradual rather than immediate.

Arthrosamid

Arthrosamid is a hydrogel injection designed for knee osteoarthritis.

• Integrates with the lining of the joint

• Aims to improve cushioning and comfort

• Typically used in more established arthritis

It is often considered by patients looking to delay or avoid surgery.

How Do You Choose the Right Injection?

This is one of the most common questions — and there isn’t a single answer.

The most appropriate option depends on:

• The underlying cause of your knee pain

• The stage of arthritis (if present)

• Your symptoms and activity level

• Your goals (e.g. pain relief vs staying active vs delaying surgery)

Two people with similar scans may need completely different approaches.

A Personalised Approach

Injections are not a one-size-fits-all solution.

The key is understanding:

• What is driving your symptoms

• What you are trying to achieve

• Which option is most appropriate at that stage

For some patients, injections can help improve comfort and function.

For others, a different approach may be more suitable.

Knee Injections in Liverpool

At The Liverpool Clinic, we guide patients through these options carefully, ensuring any treatment is tailored to the individual.

If you’ve been advised to consider an injection but feel unsure which type is right, a consultation can help you understand your options and make a clear, informed decision.

👉 You can also read our guide to knee pain and treatment options